Clinical Publications

Below is a bibliography of publications about Paragonix Technologies products and related areas of research.

Extended Static Hypothermic Preservation In Cardiac Transplantation: A Case Report
Brandon A. Guenthart*, Aravind Krishnan, Tiffany Koyano, Saverio La Francessca, Joshua Chan, Aiman Alassar, John W. Macarthur, Yasuhiro Shudo, William Hiesinger, and Y. Joseph Woo
Transplantation Proceedings, 000, 1−3 (2021) 
https://doi.org/10.1016/j.transproceed.2021.08.021

Primary Graft Dysfunction Primary Graft Dysfunction after HeartTransplantation – Unravelling the Enigma
A. Al-Adhami, S. A. Singh, S. D. De, R. Singh, G. Panjrath, A. Shah, J. R. Dalzell, J.Schroder, N. Al-Attar
Current Problems in Cardiology, 24 July, 2021
https://doi.org/10.1016/j.cpcardiol.2021.100941

First Report of the GUARDIAN Registry: An International Consortium Examining the Effect of Controlled Hypothermic Preservation in Heart Transplantation
D.D’Alessandro, J.Philpott, T. Boeve, S. Pham, A. Zuckermann
Presentation at ISHLT 2021 
https://www.jhltonline.org/article/S1053-2498(21)00412-5/abstract

Early Experience with a New Storage Device for Cold Preservation
J. Gökler, P. Angleitner, R. Moayedifar, H. Johann, A. Aliabadi-Zuckermann, G. Laufer, A. Zuckermann.
Poster at ISHLT 2021 
https://www.sciencedirect.com/science/article/abs/pii/S1053249821005866

Longest Storage Period with Static Hypothermic Preservation in Cardiac Transplantation: Initial Experience in the West Coast
B. A. Guenthart, A. Alassar, T. Koyano, S. La Francesca, J. L. Chan, A. Krishnan, J. W. MacArthur, Y. Shudo, W. Hiesinger, Y. Woo.
Poster at ISHLT 2021
https://www.jhltonline.org/article/S1053-2498(21)01319-X/abstract

Effect of Donor Heart Preservation Temperature Monitoring Technology on Primary Graft Dysfunction and Outcomes in Heart Transplantation
A. M. Tutunjian, M. Kawabori, T. Nordan, Y. Zhan, F. Y. Chen, K. G. Warner, H. Rastegar, G. S. Couper
Poster at ISHLT 2021 
https://www.jhltonline.org/article/S1053-2498(21)01320-6/abstract

Use of SherpaPak™ CTS for Organ Transportation during Heart Transplantation: First Clinical Use in United Kingdom and Outcomes
V. Mehta, A. Joshi, J. Hasan1, K. Oommen, P. Callan, S. Shaw, R. V. Venkateswaran
Poster at ISHLT 2021 
https://www.jhltonline.org/article/S1053-2498(21)00585-4/abstract

First clinical experience with the novel cold storage SherpaPak™ system for donor heart transportation
D. Radakovic, S. Karimli, J. Penov, I. Schade, K. Hamouda, C. Bening, R. Leyh, I. Aleksic
The Journal of Thoracic Disease, Dec; 12(12): 7227–7235, 2020,
DOI: https://jtd.amegroups.com/article/view/47624/html

Utilization of New Heart Preservation Technology in the Era of New Organ Allocation and Extended Ischemic Times
M. Funamoto, C.S. Ong, S.E. Kilmarx, S.S. Li, P.J. Spencer, P. Moonsamy, N. Mohan, E.E. Coglianese, G.D. Lewis
R.N. Pierson, M.A. Villavicencio-Theoduloz, D.A. D’Alessandro
The Journal of Heart and Lung Transplantation, Vol. 39, Issue 4, S136, 2020
DOI: https://doi.org/10.1016/j.healun.2020.01.1046

First Experience with a New Storage Device for Cold Preservation
J. Goekler, A. Zuckermann, P. Angleitner, E. Ceran, P. Kaiser, N. Neuber, J. Horvat, G. Laufer, A. Aliabadi-Zuckermann
The Journal of Heart and Lung Transplantation, Vol. 39, Issue 4, S244, 2020
DOI: https://doi.org/10.1016/j.healun.2020.01.924

Cool Static Storage Preservation and Transportation of Donor Hearts: Introducing New Technologies in Latin America: Paragonix SherpaPak™
A. Ameri, N. Bernal Aragon, E. Giordanino, D. Rubira, R. Ratto, L. Favaloro, R. Favaloro, M. Renedo, D. Absi, A. Bertolotti
Presentation at ISHLT 2020
https://cslide-us.ctimeetingtech.com/ishlt40th/public/share/761

The First Clinical Use of a Novel Cold Storage System of Donor Hearts
N. Naito, M. Funamoto, R. Pierson, M. Villavicencio, W. Riley, G. Lewis, D. D’Alessandro
The Journal of Heart and Lung Transplantation, Vol. 38, Issue 4, S244, 2019
DOI: https://doi.org/10.1016/j.healun.2019.01.093

Innovative cold storage of donor organs using the Paragonix Sherpa Pak ™ devices
S.G. Michel, G.M. LaMuraglia II, M.L.L Madariaga, Lisa M. Anderson
Heart, Lung and Vessels. 2015; 7(3): 246-255.
https://pubmed.ncbi.nlm.nih.gov/26495271/

Preservation of Donor Hearts Using Hypothermic Oxygenated Perfusion
S G Michel, G M La Muraglia, M L Madariaga, J S Titus, M K Selig, E A Farkash, J S Allan, L M Anderson, J C Madsen
Annals of Transplantation, 2014; 19:409-416
DOI: https://doi.org/10.12659/AOT.890797https://www.jhltonline.org/article/S1053-2498(21)00412-5/abstract

Cold Injury

Organ transport temperature box: multicenter study on transport temperature of organs
D F Horch, T Mehlitz, O Laurich, A Abel, S Reuter, H Pratschke, P Neuhaus, C Wesslau 
Transplant Proceedings, Vol. 34, Issue 6, 2002
DOI: https://doi.org/10.1016/s0041-1345(02)03253-0

Are temperatures attained by donor hearts during transport too cold?
P J Hendry, V M Walley, A Koshal, R G Masters, W J Keon
The Journal of Thoracic and Cardiovascular Surgery, Volume 98, Issue 4, 1989
DOI: https://doi.org/10.1016/S0022-5223(19)34352-1

Effect of temperature in long-term preservation of vascular endothelial and smooth muscle function
R Ingemansson, A Budrikis, R Bolys, T Sjöberg, S Steen
The Annals of Thoracic Surgery, Volume 61, Issue 5, 1996
DOI: https://doi.org/10.1016/0003-4975(96)00109-9

Endothelial dysfunction caused by University of Wisconsin preservation solution in the rat heart: The importance of temperature
The Journal of Thoracic and Cardiovascular Surgery, Volume 104, Issue 6, 1992
P Mankad, Z Slavik, M Yacoub
DOI: https://doi.org/10.1016/S0022-5223(19)33892-9

Cardiac Transplantation: The Ideal Myocardial Temperature for Graft Transport
W J Keon, P J Hendry, G C Taichman, G W Mainwood
The Annals of Thoracic Surgery, Volume 46, Issue 3, 1988
DOI: https://doi.org/10.1016/S0003-4975(10)65939-5

Preservation & Transport

Static lung storage at 10°C maintains mitochondrial health and preserves donor organ function
Aadil Ali, Aizhou Wang, Rafaela V. P. Ribeiro, Erika L. Beroncal, Cristina Baciu, Marcos Galasso, Bruno Gomes, Andrea Mariscal, Olivia Hough, Edson Brambate, Etienne Abdelnour-Berchtold, Vinicius Michaelsen, Yu Zhang, Anajara Gazzalle, Eddy Fan, Laurent Brochard, Jonathan Yeung, Tom Waddell, Mingyao Liu, Ana C. Andreazza, Shaf Keshavjee, Marcelo Cypel
Sci. Transl. Med. 13, eabf7601 (2021) 15 September 2021
DOI: 10.1126/scitranslmed.abf7601 

One-Year Monitoring of Heart Allocation Proposal to Modify the Heart Allocation System
K Lindblad, R R Goff
Final Report for OPTN Thoracic Committee, 2020
DOI: https://optn.transplant.hrsa.gov/media/3701/data_report_thoracic_committee_heart_subcommittee_20200227_rpt1_revised_508_compliant.pdf

Donor heart and lung procurement: A consensus statement
H Copeland, J W Awori Hayanga, A Neyrinck, P MacDonald, G Dellgren, A Bertolotti, T Khuu, F Burrows, J G Copeland, D Gooch, A Hackmann, D Hormuth, C Kirk, V Linacre, H Lyster, S Marasco, D McGiffin, P Nair, A Rahmel, M Sasevich, M Schweiger, A Siddique, T J Snyder, W Stansfield, S Tsui, Y Orr, P Uber, R Venkateswaran, J Kukreja, M Mulligan
The Journal of Heart and Lung Transplantation, Vol. 39, Issue 6, 2020
DOI: https://doi.org/10.1016/j.healun.2020.03.020

Primary Graft Dysfunction

Cost Implications of Mechanical Circulatory Support for Primary Graft Dysfunction Following Heart Transplantation
A.A. Ali, M. Schechter, K. Southerland, L. Harling, J. Schroder, C. Milano
The Journal of Heart and Lung Transplantation, Vol. 34, Issue 4, 2015
DOI: https://doi.org/10.1016/j.healun.2015.01.8257

Outcomes of the First 1300 Adult Heart Transplants in the United States After the Allocation Policy Change
Arman Kilic, Gavin Hickey, Michael A. Mathier, Robert L. Kormos, Ibrahim Sultan, Thomas G. Gleason, Mary E. Keebler
Circulation, Vol. 141, Issue 20, 2020
DOI: https://doi.org/10.1161/CIRCULATIONAHA.119.045354

Report from a consensus conference on primary graft dysfunction after cardiac transplantation
J Kobashigawa, A Zuckermann, P Macdonald, P Leprince, F Esmailian, M Luu, D Mancini, J Patel, R Razi, H Reichenspurner, S Russell, J Segovia, N Smedira, J Stehlik, F Wagner
The Journal of Heart and Lung Transplantation, Vol. 33, Issue 4, 2014
DOI: https://doi.org/10.1016/j.healun.2014.02.027

PREDICTA: A Model to Predict Primary Graft Dysfunction After Adult Heart Transplantation in the United Kingdom
S A Singh, S Das De, S Rushton, C Berry, N Al-Attar
Journal of Cardiac Failure, Vol. 25, Issue 12, 2019
DOI: https://doi.org/10.1016/j.cardfail.2019.07.009

Primary graft dysfunction after heart transplantation: Incidence, trends, and associated risk factors
A Nicoara, D Ruffin, M Cooter, C B Patel, A Thompson, J N Schroder, M A Daneshmand, A F Hernandez, J G Rogers, M V Podgoreanu, M Swaminathan, A Kretzer, M Stafford‐Smith, C A Milano, R R Bartz
American Journal of Transplantation, Vol. 18, Issue 6, 2017
DOI: https://doi.org/10.1111/ajt.14588

Incidence, predictors, and outcomes after severe primary graft dysfunction in pediatric heart transplant recipients
E L Profita, K Gauvreau, P Rycus, R Thiagarajan, T P Singh
The Journal of Heart and Lung Transplantation, Vol. 38, Issue 6, 2019
DOI: https://doi.org/10.1016/j.healun.2019.01.1310