Literature Relating to Paragonix
The below-listed literature is intended to provide the reader with scientific literature that reviews various aspects of the current methods of donor organ storage on ice. Abstracts and relevant information taken from the published articles highlight the need for:
Authors: Andreas Zuckermann, Johannes Gökler, Phillip Kaiser, Enise Ceran , Nina Neuber, Günther Laufer, Arezu Aliabadi-Zuckermann BackgroundThe standard technology for heart preservation for transplantation is cold static storage on ice. No temperature control is performed routinely and therefore lower or higher temperatures can occur leading to injury of the graft.
BACKGROUND: Hypothermic machine perfusion of donor hearts enables continuous aerobic metabolism and washout of toxic metabolic byproducts. We evaluated the effect of machine perfusion on cardiac myocyte integrity in hearts preserved for 4 h in a novel device that provides pulsatile oxygenated hypothermic perfusion (Paragonix Sherpa Perfusion™ Cardiac Transport System).
The authors of this international consensus paper note in Table 1 the results of an online survey on the prevention of primary graft dysfunction after cardiac transplantation. “Precautions against PGD: (descending order of importance) Cooling of the heart during implantation (by using devices such as cooling jackets, ice, cooling via vent
“Appropriate hypothermic packaging techniques are an essential part of organ procurement. We present a case in which deviation from standard packaging practice may have caused sub‐zero storage temperatures during transport, resulting in a clinical picture resembling PNF. An 18‐month‐old male with alpha‐1‐antitrypsin deficiency underwent liver transplant from a size‐matched pediatric
Predictive Risk Factors For Primary Graft Failure Requiring Temporary Extra-Corporeal Membrane Oxygenation Support After Cardiac Transplantation In Adults
Primary graft failure (PGF) is a major risk factor for death after heart transplantation. We investigated the predictive risk factors for severe PGF that require extra-corporeal membrane oxygenation (ECMO) circulatory support after cardiac transplantation.
“Cold storage of the heart is one of the most challenging fields for organ preservation because of the high sensitivity of cardiac muscle to hypoxic injury and the serious perioperative consequences of inadequate preservation, leading to poor early graft function with associated high morbidities and mortalities. Careful selection of donor hearts is mandated.”