Literature Relating to Paragonix

The below-listed literature is intended to provide the reader with scientific literature that reviews various aspects of the current methods of donor organ storage on ice. Abstracts and relevant information taken from the published articles highlight the need for:

Organ Preservation: Current Concepts & New Strategies For The Next Decade

“Cold storage of the heart is one of the most challenging fields for organ preservation because of the high sensitivity of cardiac muscle to hypoxic injury and the serious perioperative consequences of inadequate preservation, leading to poor early graft function with associated high morbidities and mortalities. Careful selection of donor hearts is mandated.”

The Relevance Of Ice Crystal Formation For The Cryopreservation Of Tissues & Organs

This paper discusses the role of ice crystal formation in causing or contributing to the difficulties that have been encountered in attempts to develop effective methods for the cryopreservation of some tissues and all organs. It is shown that extracellular ice can be severely damaging but also that cells in situ in tissues can behave quite differently from similar cells in a suspension with respect to intracellular freezing.

Organ Reperfusion & Preservation

Organ transplantation is one of the medical success stories of the 20th century. Transplantation is, however, a victim of its own success with demand for

Are Temperatures Attained by Donor Hearts During Transport Too Cold?

Excessive myocardial cooling may have detrimental effects on donor heart integrity. This study assessed the standard technique for donor myocardial preservation using hearts from seven mongrel dogs (mean weight 192.7 gm), which were arrested, excised, and placed in a cooler containing saline and ice.

Improved Myocardial Preservation At 4 Degrees C°

We tested the ability of various cardiac preservation techniques to preserve left ventricular function of isolated canine hearts using preservation temperatures of 4 degrees or 15 degrees C°.