Literature Relating to Paragonix
The below-listed literature is intended to provide the reader with scientific literature that reviews various aspects of the current methods of donor organ storage on ice. Abstracts and relevant information taken from the published articles highlight the need for:
Authors: Andreas Zuckermann, Johannes Gökler, Phillip Kaiser, Enise Ceran , Nina Neuber, Günther Laufer, Arezu Aliabadi-Zuckermann BackgroundThe standard technology for heart preservation for transplantation is
BACKGROUND: Hypothermic machine perfusion of donor hearts enables continuous aerobic metabolism and washout of toxic metabolic byproducts. We evaluated the effect of machine perfusion on
The authors of this international consensus paper note in Table 1 the results of an online survey on the prevention of primary graft dysfunction after
“Appropriate hypothermic packaging techniques are an essential part of organ procurement. We present a case in which deviation from standard packaging practice may have caused
Predictive Risk Factors For Primary Graft Failure Requiring Temporary Extra-Corporeal Membrane Oxygenation Support After Cardiac Transplantation In Adults
Primary graft failure (PGF) is a major risk factor for death after heart transplantation. We investigated the predictive risk factors for severe PGF that require extra-corporeal membrane oxygenation (ECMO) circulatory support after cardiac transplantation.
“Cold storage of the heart is one of the most challenging fields for organ preservation because of the high sensitivity of cardiac muscle to hypoxic injury and the serious perioperative consequences of inadequate preservation, leading to poor early graft function with associated high morbidities and mortalities. Careful selection of donor hearts is mandated.”
Primary graft failure (PGF) is a devastating complication that occurs in the immediate postoperative period following heart transplantation. It manifests as severe ventricular dysfunction of
This paper discusses the role of ice crystal formation in causing or contributing to the difficulties that have been encountered in attempts to develop effective methods for the cryopreservation of some tissues and all organs. It is shown that extracellular ice can be severely damaging but also that cells in situ in tissues can behave quite differently from similar cells in a suspension with respect to intracellular freezing.
Organ transplantation is one of the medical success stories of the 20th century. Transplantation is, however, a victim of its own success with demand for
Accumulation of Crystal Deposits In Abdominal Organs Following Perfusion With Defrosted University Of Wisconsin Solutions
Previous studies reported on both visible and invisible particles in University of Wisconsin (UW) solutions. Those particles originated from components of the bags. In recent clinical observations we noticed macroscopically visible, indissoluble particles in UW bags reaching subzero temperatures during transportation of organs and preservation solutions
Excessive myocardial cooling may have detrimental effects on donor heart integrity. This study assessed the standard technique for donor myocardial preservation using hearts from seven mongrel dogs (mean weight 192.7 gm), which were arrested, excised, and placed in a cooler containing saline and ice.
We tested the ability of various cardiac preservation techniques to preserve left ventricular function of isolated canine hearts using preservation temperatures of 4 degrees or 15 degrees C°.