Utilization of New Heart Preservation Technology in the Era of New Organ Allocation and Extended Ischemic Times
Funamoto, et al.Journal of Heart and Lung TransplantationApril 2019; Volume 38, Issue 4, S44.https://doi.org/10.1016/j.healun.2020.01.1046 Purpose : Current ice bag heart preservation technique is associated with wide
Naito, et al.Journal of Heart and Lung TransplantationApril 2019; Volume 38, Issue 4, S44.https://doi.org/10.1016/j.healun.2019.01.093 Purpose : Current cold storage heart preservation technique is associated with wide
Currently, the gold standard for donor organ preservation in clinical organ transplantation consists of 3 plastic bags and an ice box. The first plastic bag includes the organ itself immersed in preservation solution (e.g. Celsior).
Bunegin L, Tolstykh GP, Gelineau JF, Cosimi AB, Anderson LMASAIO Journal2013 Jul-Aug; 59(4):427-32https://www.ncbi.nlm.nih.gov/pubmed/23820283 Hypothermic machine perfusion (HMP) for the preservation of kidneys, recovered from extended criteria
Novel portable hypothermic pulsatile perfusion preservation technology: Improved viability and function of rodent and canine kidneys.
A reliable, portable, cost effective device for perfusion preservation of donor organs remains elusive. A portable, organ perfusion device design for hypothermic, machine perfusion (HMP) that successfully supported rodent kidneys for 24 hours was evaluated in canine kidneys.
Abstract A prototype design of a portable, pulsatile, perfusion preservation device based on a novel application of fluidics technology was tested to evaluate its ability to oxygenate preservation
Cardiac transplantation is limited to an ischemic time of around 6 hours by available preservation solution and technique. Complex organ preservation devices have been developed that extend this time to 24 hours or more, but are clinically impractical. This study evaluates a portable oxygen-driven organ perfusion device weighing approximately 13.5 kg.