Naito, et al.Journal of Heart and Lung TransplantationApril 2019; Volume 38, Issue 4, S44.https://doi.org/10.1016/j.healun.2019.01.093 Purpose : Current cold storage heart preservation technique is associated with wide fluctuation of organ temperature and may result in freeze injury. SheraPak™ Cardiac Transport System (CTS) (Paragonix Technologies, MA, USA) was recently approved in the United
Currently, the gold standard for donor organ preservation in clinical organ transplantation consists of 3 plastic bags and an ice box. The first plastic bag includes the organ itself immersed in preservation solution (e.g. Celsior).
Bunegin L, Tolstykh GP, Gelineau JF, Cosimi AB, Anderson LMASAIO Journal2013 Jul-Aug; 59(4):427-32https://www.ncbi.nlm.nih.gov/pubmed/23820283 Hypothermic machine perfusion (HMP) for the preservation of kidneys, recovered from extended criteria organ donors (ECDs), presents the opportunity for assessing ex vivo parameters that may have value in predicting postimplantation organ viability. Organ perfusion and vascular resistance are the
Novel portable hypothermic pulsatile perfusion preservation technology: Improved viability and function of rodent and canine kidneys.
A reliable, portable, cost effective device for perfusion preservation of donor organs remains elusive. A portable, organ perfusion device design for hypothermic, machine perfusion (HMP) that successfully supported rodent kidneys for 24 hours was evaluated in canine kidneys.
Abstract A prototype design of a portable, pulsatile, perfusion preservation device based on a novel application of fluidics technology was tested to evaluate its ability to oxygenate preservation solution and to examine the relationship between organ resistance, perfusion pressure, and perfusion flow characteristics. The effects of organ resistance on pulse rate, perfusion pressure, and perfusion flow were modeled. Interstitial PO2 in