Clinical Research Publications

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Cardiac Transport System

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Innovative cold storage of donor organs using the Paragonix SherpaPak ™ devices

Heart, Lung and Vessels. 2015; 7(3): 246-255.

S.G. Michel, G.M. LaMuraglia II, M.L.L Madariaga, Lisa M. Anderson

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Cardiac Transport System

GUARDIAN Publications

Heart

Myocardial Protection in Donor Heart Preservation: Could we improve the procurement?

Presentation at EACTS 2020

A. Eixerés Esteve, E. Pérez de la Sota, C. Barajas Díaz, V. Benito Arnaiz, J. Centeno Rodríguez, M.J. López Gude, E.M. Aguilar Blanco. J.M. Cortina Romero

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Cardiac Transport System

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Preservation Modalities

GUARDIAN Publications

Keep Your Cool! One Year Outcomes with Use of a Hypothermic Preservation System Compared to Standard Storage with Ice During Heart Procurement

The Journal of Heart and Lung Transplantation, Vol. 41, Issue 4, S201, April 2022

J. Teuteberg, E. Henricksen, K. Khush, D.T. Kim, Y. Moayedi, H. Luikart, R. Wainwright, J.Y. Woo, W. Hiesinger, T. Koyano, Y. Shudo

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Cardiac Transport System

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GUARDIAN Publications

Pediatrics

First Report of Pediatric Outcomes from the GUARDIAN Registry: Multi-Center Analysis of Advanced Organ Preservation for Pediatric Recipients

The Journal of Heart and Lung Transplantation, Vol. 41, Issue 4, S477, April 2022

J. Jacobs, J. Schroder, U. Boston, and A. Zuckermann

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GUARDIAN Publications

Heart

Cardiac Transport System

Preservation Modalities

Second Report of the GUARDIAN Registry: An International Consortium Examining the Effect of Controlled Hypothermic Preservation in Heart Transplantation

The Journal of Heart and Lung Transplantation, Vol. 41, Issue 4, S477, April 2022

A. Zuckermann, M. Leacche, J. Philpott, S. Pham, Y. Shudo, J. Bustamante-Munguira, J. Jacobs, S. Silvestry, J. Schroder, A. Eixeres- Esteve, E. Molina, D. Meyer, M. Kawabori, and D. D’Alessandro

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Heart

Initial Experiences

GUARDIAN Publications

Austrian Analysis of the GUARDIAN Registry: Heart Transplant Effects in Europe from the Global Pandemic

The Journal of Heart and Lung Transplantation, Vol. 41, Issue 4, S51, April 2022

R. Moayedifar, P. Angleitner, J. Gëokler, E. Osorio, J. Horvat, C. Atteneder, A. Aliabadi-Zuckermann, G. Laufer and A. Zuckermann

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Cardiac Transport System

GUARDIAN Publications

Heart

Donation after Circulatory Death

Evaluation of Safety and Effectiveness of the Paragonix™ SherpaPak Cardiac Transport System in Donation After Circulatory Death Heart Transplantation (clinicaltrials.gov Identifier: Nct05038943)

The Journal of Heart and Lung Transplantation, Vol. 41, Issue 4, S476, April 2022

M. Urban, A. Castleberry, B. Lowes, M. Moody, L. Fristo, A. Siddique, and J. Um

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Cardiac Transport System

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Ischemic Time

How long can we go? Redefining the Upper Limit of Ischemic Times for Hypothermic Donor Heart Preservation

The Journal of Heart and Lung Transplantation, Vol. 42, Issue 4, S278, April 2023’

K. Takeda, S. Silvestry, J. Schroder, D. D'Alessandro, M. Leacche, C. Sciortino, S. M. Pham, A. Vidic, D. Meyer, M. Kawabori, Y. Shudo

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Cardiac Transport System

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Pediatrics

GUARDIAN Publications

Outcomes in Children and Young Adults with Congenital Heart Disease Undergoing Transplant: A Subgroup Analysis of the GUARDIAN Heart Registry

The Journal of Heart and Lung Transplantation, Vol. 42, Issue 4, S268, April 2023

U. Boston, A. Zuckermann, Y. Stukov, J. Schroder, Y. Shudo, J. Bustamante-Munguira, M. Leacche, S. Silvestry, M. Kawabori, K. Takeda, J. P. Jacobs

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Cardiac Transport System

Heart

GUARDIAN Publications

Improved Outcomes in Older Recipients Undergoing Transplant Using the SherpaPak System: A Subgroup Analysis of the GUARDIAN Heart Registry

The Journal of Heart and Lung Transplantation, Vol. 42, Issue 4, S288, April 2023

H. Copeland, M. Leacche, D. D'Alessandro, C. Sciortino, J. Schroder, S. M. Pham, M. Rodrigo, S. Silvestry, M. Kawabori, Y. Shudo, D. Meyer

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Cardiac Transport System

Preservation Modalities

The Effect of Temperature Control Versus Icebox Preservation on Post Heart Transplant Outcome

The Journal of Heart and Lung Transplantation, Vol. 42, Issue 4, S221, April 2023

F. Latif, G. Sayer, D. Lotan, J. Mendoza, M. Regan, D. Tsapepas, A. Ramakrishnan, E. M. DeFilippis, M. Yuzefpolskaya, P. Colombo, P. Kennel, J. Raikhelkar, K. Clerkin, J. Fried, E. Lin, S. Lee, Y. Naka, K. Takeda, N. Uriel

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Cardiac Transport System

Heart

Mechanical Circulatory Support

GUARDIAN Publications

Preservation Modalities

Use of the SherpaPak Cardiac Transport System Improves Freedom from Requirement for Mechanical Circulatory Support, Reduced Early Acute Cellular Rejection and Preserves Early Lv Function When Compared to Conventional Cold Storage

The Journal of Heart and Lung Transplantation, Vol. 42, Issue 4, S416-417, April 2023

B. Krishnamoorthy, W. Critchley, N. Nwaejike, V. Mehta, P. Callan, S. Shaw, J. Barnard, R. Venkateswaran

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Cardiac Transport System

GUARDIAN Publications

Recipient Outcomes with Extended Criteria Donors: An Analysis of the Guardian Heart Registry

The Journal of Heart and Lung Transplantation, Vol. 42, Issue 4, S31-32, April 2023

R. Moayedifar, Y. Shudo, M. Kawabori, S. Silvestry, J. Schroder, D. Meyer, D. D'Alessandro, and A. Zuckermann

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GUARDIAN Publications

Pediatrics

Donor Heart Preservation Strategy Using a Cold Storage System for Pediatric Heart Transplantation

The Journal of Heart and Lung Transplantation, Vol. 42, Issue 4, S46-47, April 2023

C. Buyukgoz, M. Absi, H.R. Martinez, T. Street, R. Siddique, and U. Boston

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GUARDIAN Publications

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Cardiac Transport System

Results from over 800 Transplant Recipients Enrolled in the Guardian Heart Registry

The Journal of Heart and Lung Transplantation, Vol. 42, Issue 4, S63-64, April 2023

D. D'Alessandro, Y. Shudo, D. Meyer, S. Silvestry, M. Leacche, C. Sciortino, M. Rodrigo, S.M. Pham, J.P. Jacobs, K. Takeda, H. Copeland, A. Vidic, M. Kawabori, and J. Schroder

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Cardiac Transport System

GUARDIAN Publications

Heart

Validating the 2014 Consensus Primary Graft Definition: An Analysis on the 1,056 Patients from the Multi-Center Guardian Registry

The Journal of Heart and Lung Transplantation, Vol. 42, Issue 4, S72-73, April 2023

A. Zuckermann, J.P. Jacobs, Y. Shudo, D. Meyer, S. Silvestry, M. Leacche, C. Sciortino, M. Rodrigo, S. Pham, K. Takeda, H. Copeland, A. Vidic, M. Kawabori, U. Boston, J. Bustamante- Munguira, A. Eixeres Esteve, R. Venkateswaran, J. Schroder, and D. D'Alessandro

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Heart

Cardiac Transport System

GUARDIAN Publications

Pediatrics

Pediatric Experience Using the Sherpapak Cardiac Transport System: A Subgroup Analysis of the Guardian Heart Registry

The Journal of Heart and Lung Transplantation, Vol. 42, Issue 4, S92, April 2023

J.P. Jacobs, U. Boston, Y. Stukov, J. Schroder, J. Bustamante-Munguira, A. Zuckermann

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Cardiac Transport System

Heart

Preservation Modalities

GUARDIAN Publications

Graft Preservation in Heart Transplantation: Clinical and Histological Results Using Three Different Techniques

The Journal of Heart and Lung Transplantation, Vol. 42, Issue 4, S145, April 2023

A. Lechiancole, S. Sponga, I. Vendramin, V. Ferrara, G. Benedetti, G. Guzzi, C. Nalli, C. Di Nora, R.M. Calandruccio, Y. Brindicci, M. Bressan, and U. Livi

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Cardiac Transport System

Heart

Preservation Modalities

GUARDIAN Publications

Leveraging Advanced Hypothermic Preservation to Achieve Transplant Program Goals

The Journal of Heart and Lung Transplantation, Vol. 42, Issue 4, S185, April 2023

J. Schroder, M. Leacche, C. Sciortino, Y. Shudo, M. Rodrigo, D. Meyer, M. Kawabori, and D. D'Alessandro

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Cardiac Transport System

Initial Experiences

Evaluating Heart Transplant Outcomes Utilizing the Sherpapak Heart Storage System

The Journal of Heart and Lung Transplantation, Vol. 42, Issue 4, S186, April 2023

S. Finkbiner, J. Mancuso, T. Dalia, J. Baer, H. Farhoud, M. Danter, T. Zorn, J. Hu, J. Baker, H. Shah, Z. Shah, P. Downey and A. Vidic

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Cardiac Transport System

GUARDIAN Publications

Heart

Ischemic Time

Role of Sherpapak in Donors with Drug Overdose and Long Ischemic Times

The Journal of Heart and Lung Transplantation, Vol. 42, Issue 4, S187, April 2023

J. Baer, A. Malhotra, T. Dalia, J. Mancuso, T. Zorn, P. Downey, D. D'Alessandro, D. Meyer, S. Greer, H. Shah, Z. Shah, M. Danter, S. Silvestry, and A. Vidic

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Cardiac Transport System

Ischemic Time

Heart

Mechanical Circulatory Support

GUARDIAN Publications

Sherpapak Reduces Mcs Use Post Heart Transplant in Long Donor Down and Ischemic Times

The Journal of Heart and Lung Transplantation, Vol. 42, Issue 4, S187, April 2023

J. Baer, A. Malhotra, T. Dalia, J. Mancuso, T. Zorn, P. Downey, D. D'Alessandro, D. Meyer, S. Greer, H. Shah, Z. Shah, M. Danter, S. Silvestry, and A. Vidic

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Cardiac Transport System

Heart

Initial Experiences

Pediatrics

GUARDIAN Publications

Use of the SherpaPak Cardiac Transport System for Infant and Pediatric Donor Hearts: An Initial Experience

The Journal of Heart and Lung Transplantation, Vol. 42, Issue 4, S187-188, April 2023

E. L. Profita, E. Lee, M. Ma, E. Martin, S. Hollander, D. Rosenthal, T. Nasirov, C. Almond

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Cardiac Transport System

Heart

GUARDIAN Publications

Ischemic Time

Can Controlled Hypothermic Preservation Provide Clinical Benefits in the Setting of Shorter Ischemic Times Prior to Heart Transplant?

The Journal of Heart and Lung Transplantation, Vol. 42, Issue 4, S189, April 2023

D. Meyer, Y. Shudo, J. Schroder, D. D'Alessandro, S. Silvestry, C. Sciortino, S. M. Pham, M. Rodrigo, J. P. Jacobs, M. Kawabori, K. Takeda, M. Leacche

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Cardiac Transport System

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GUARDIAN Publications

Multicenter Registry Using Propensity Score Analysis to Compare a Novel Transport/Preservation System to Traditional Means on Postoperative Hospital Outcomes and Costs for Heart Transplant Patients

ASAIO J, 2022 November 18

JD Voigt, M Leacche, H Copeland, SB Wolfe, SM Pham, Y Shudo, E Molina, JP Jacobs, Y Stukov, D Meyer, J Philpott, M Kawabori, J Schroder, S Silvestry, D D’Alessandro

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Heart

Preservation Modalities

Heart Donation and Preservation: Historical Perspectives, Current Technologies, and Future Directions.

J Clin Med. 2022 September 28; Volume 11, Number 19, pp:5762

NR Hess, LA Ziegler, DJ Kaczorowski

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Heart

Cardiac Transport System

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A Simple Technique for Reliable Donor Organ Temperature Management with the SherpaPak System

ASAIO Journal, Volume 68, Issue 8, August 2022, pages e134-e135

M. Kawabori, D.A. Posawatz, F.Y. Chen, G.S. Couper

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Heart

Cardiac Transport System

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Outcomes of Heart Transplantation Using a Temperature-controlled Hypothermic Storage System

Transplantation 107(5):p 1151-1157, May 2023.

Y. Zhu, Y. Shudo, H. He, J-Y. Kim, S. Elde, K.M. Williams, S.K. Walsh, T.K. Koyano, B. Guenthart, Y.J. Woo

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Initial Experiences

Cardiac Transport System

Heart

Keeping your cool: Donor heart preservation using the SherpaPak Cardiac Transport System

The Journal of Thoracic and Cardiovascular Surgery, Volume159, Issue 2, 2019

A Iyengar, P Atluri

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Heart

Primary Graft Dysfunction

Incidence, predictors, and outcomes after severe primary graft dysfunction in pediatric heart transplant recipients

The Journal of Heart and Lung Transplantation, Vol. 38, Issue 6

E L Profita, K Gauvreau, P Rycus, R Thiagarajan, T P Singh

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Heart

Primary Graft Dysfunction

Primary graft dysfunction after heart transplantation: Incidence, trends, and associated risk factors

American Journal of Transplantation, Vol. 18, Issue 6

A Nicoara, D Ruffin, M Cooter, C B Patel, A Thompson, J N Schroder, M A Daneshmand, A F Hernandez, J G Rogers, M V Podgoreanu, M Swaminathan, A Kretzer, M Stafford‐Smith, C A Milano, R R Bartz

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Heart

Primary Graft Dysfunction

PREDICTA: A Model to Predict Primary Graft Dysfunction After Adult Heart Transplantation in the United Kingdom

Journal of Cardiac Failure, Vol. 25, Issue 12

S A Singh, S Das De, S Rushton, C Berry, N Al-Attar

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Heart

Primary Graft Dysfunction

Report from a consensus conference on primary graft dysfunction after cardiac transplantation

The Journal of Heart and Lung Transplantation, Vol. 33, Issue 4

J Kobashigawa, A Zuckermann, P Macdonald, P Leprince, F Esmailian, M Luu, D Mancini, J Patel, R Razi, H Reichenspurner, S Russell, J Segovia, N Smedira, J Stehlik, F Wagner

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Heart

Primary Graft Dysfunction

Cost Implications of Mechanical Circulatory Support for Primary Graft Dysfunction Following Heart Transplantation

The Journal of Heart and Lung Transplantation, Vol. 34, Issue 4

A.A. Ali, M. Schechter, K. Southerland, L. Harling, J. Schroder, C. Milano

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Heart

Primary Graft Dysfunction

Outcomes of the First 1300 Adult Heart Transplants in the United States After the Allocation Policy Change

Circulation, Vol. 141, Issue 20

Arman Kilic, Gavin Hickey, Michael A. Mathier, Robert L. Kormos, Ibrahim Sultan, Thomas G. Gleason, Mary E. Keebler

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Heart

Lung

Donor heart and lung procurement: A consensus statement

The Journal of Heart and Lung Transplantation, Vol. 39, Issue 6

H Copeland, J W Awori Hayanga, A Neyrinck, P MacDonald, G Dellgren, A Bertolotti, T Khuu, F Burrows, J G Copeland, D Gooch, A Hackmann, D Hormuth, C Kirk, V Linacre, H Lyster, S Marasco, D McGiffin, P Nair, A Rahmel, M Sasevich, M Schweiger, A Siddique, T J Snyder, W Stansfield, S Tsui, Y Orr, P Uber, R Venkateswaran, J Kukreja, M Mulligan

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Heart

One-Year Monitoring of Heart Allocation Proposal to Modify the Heart Allocation System

Final Report for OPTN Thoracic Committee

K Lindblad, R R Goff

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Lung

Static lung storage at 10°C maintains mitochondrial health and preserves donor organ function

Sci. Transl. Med. 13

Aadil Ali, Aizhou Wang, Rafaela V. P. Ribeiro, Erika L. Beroncal, Cristina Baciu, Marcos Galasso, Bruno Gomes, Andrea Mariscal, Olivia Hough, Edson Brambate, Etienne Abdelnour-Berchtold, Vinicius Michaelsen, Yu Zhang, Anajara Gazzalle, Eddy Fan, Laurent Brochard, Jonathan Yeung, Tom Waddell, Mingyao Liu, Ana C. Andreazza, Shaf Keshavjee, Marcelo Cypel

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Cold Injury

Cardiac Transplantation: The Ideal Myocardial Temperature for Graft Transport

The Annals of Thoracic Surgery, Volume 46, Issue 3

W J Keon, P J Hendry, G C Taichman, G W Mainwood

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Cold Injury

Endothelial dysfunction caused by University of Wisconsin preservation solution in the rat heart: The importance of temperature

The Journal of Thoracic and Cardiovascular Surgery, Volume 104, Issue 6

P Mankad, Z Slavik, M Yacoub

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Cold Injury

Effect of temperature in long-term preservation of vascular endothelial and smooth muscle function

The Annals of Thoracic Surgery, Volume 61, Issue 5

R Ingemansson, A Budrikis, R Bolys, T Sjöberg, S Steen

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Cold Injury

Are temperatures attained by donor hearts during transport too cold?

The Journal of Thoracic and Cardiovascular Surgery, Volume 98, Issue 4

P J Hendry, V M Walley, A Koshal, R G Masters, W J Keon

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Cold Injury

Organ transport temperature box: multicenter study on transport temperature of organs

Transplant Proceedings, Vol. 34, Issue 6

D F Horch, T Mehlitz, O Laurich, A Abel, S Reuter, H Pratschke, P Neuhaus, C Wesslau

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Heart

Preservation of Donor Hearts Using Hypothermic Oxygenated Perfusion

Annals of Transplantation

S.G. Michel, G.M. La Muraglia, M.L. Madariaga, J.S. Titus, M.K. Selig, E.A. Farkash, J.S. Allan, L.M. Anderson, J.C. Madsen

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Cardiac Transport System

Heart

Innovative cold storage of donor organs using the Paragonix SherpaPak™ devices

Heart Lung Vessel

S.G. Michel, G.M. LaMuraglia II, M.L.L Madariaga, Lisa M. Anderson

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Cardiac Transport System

Heart

Initial Experiences

GUARDIAN Publications

The First Clinical Use of a Novel Cold Storage System of Donor Hearts

The Journal of Heart and Lung Transplantation, Vol. 38, Issue 4, S244, 2019

N. Naito, M. Funamoto, R. Pierson, M. Villavicencio, W. Riley, G. Lewis, D. D’Alessandro

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Cardiac Transport System

Heart

Initial Experiences

GUARDIAN Publications

Cool Static Storage Preservation and Transportation of Donor Hearts: Introducing New Technologies in Latin America: Paragonix SherpaPak™

Presentation at ISHLT 2020

A. Ameri, N. Bernal Aragon, E. Giordanino, D. Rubira, R. Ratto, L. Favaloro, R. Favaloro, M. Renedo, D. Absi, A. Bertolotti

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Cardiac Transport System

Heart

Initial Experiences

GUARDIAN Publications

First Experience with a New Storage Device for Cold Preservation

The Journal of Heart and Lung Transplantation, Vol. 39, Issue 4

J. Goekler, A. Zuckermann, P. Angleitner, E. Ceran, P. Kaiser, N. Neuber, J. Horvat, G. Laufer, A. Aliabadi-Zuckermann

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Cardiac Transport System

Heart

GUARDIAN Publications

Utilization of New Heart Preservation Technology in the Era of New Organ Allocation and Extended Ischemic Times

The Journal of Heart and Lung Transplantation, Vol. 39, Issue 4

M. Funamoto, C.S. Ong, S.E. Kilmarx, S.S. Li, P.J. Spencer, P. Moonsamy, N. Mohan, E.E. Coglianese, G.D. Lewis, R.N. Pierson, M.A. Villavicencio-Theoduloz, D.A. D’Alessandro

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Cardiac Transport System

Heart

Initial Experiences

First clinical experience with the novel cold storage SherpaPak™ system for donor heart transportation

The Journal of Thoracic Disease

D. Radakovic, S. Karimli, J. Penov, I. Schade, K. Hamouda, C. Bening, R. Leyh, I. Aleksic

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Cardiac Transport System

Heart

Initial Experiences

GUARDIAN Publications

Use of SherpaPak™ CTS for Organ Transportation during Heart Transplantation: First Clinical Use in United Kingdom and Outcomes

The Journal of Heart and Lung Transplantation, Vol. 40, Issue 4

V. Mehta, A. Joshi, J. Hasan, K. Oommen, P. Callan, S. Shaw, R. V. Venkateswaran

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Cardiac Transport System

Heart

Primary Graft Dysfunction

GUARDIAN Publications

Effect of Donor Heart Preservation Temperature Monitoring Technology on Primary Graft Dysfunction and Outcomes in Heart Transplantation

The Journal of Heart and Lung Transplantation, Vol. 40, Issue 4

A. M. Tutunjian, M. Kawabori, T. Nordan, Y. Zhan, F. Y. Chen, K. G. Warner, H. Rastegar, G. S. Couper

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Cardiac Transport System

Heart

Initial Experiences

GUARDIAN Publications

Ischemic Time

Longest Storage Period with Static Hypothermic Preservation in Cardiac Transplantation: Initial Experience in the West Coast

The Journal of Heart and Lung Transplantation, Vol. 40, Issue 4

B. A. Guenthart, A. Alassar, T. Koyano, S. La Francesca, J. L. Chan, A. Krishnan, J. W. MacArthur, Y. Shudo, W. Hiesinger, Y. Woo

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Cardiac Transport System

Heart

Initial Experiences

An innovative cold storage system for donor heart transportation— lessons learned from the first experience in Switzerland

Transplantation Journal of Thoracic Disease

Martin O. Schmiady, Tim Graf, Ahmed Ouda, Raed Aser, Andreas J. Flammer, Paul R. Vogt, Markus J. Wilhelm

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Cardiac Transport System

Heart

Initial Experiences

Extended Static Hyopthermic Preservation in Cardiac Transplantation: A Case Report

Transplantation Proceedings, 000, 1−3

Brandon A. Guenthart, Aravind Krishnan, Tiffany Koyano, Saverio La Francessca, Joshua Chan, Aiman Alassar, John W. Macarthur, Yasuhiro Shudo, William Hiesinger, and Y. Joseph Woo

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Cardiac Transport System

Heart

Initial Experiences

GUARDIAN Publications

Early Experience with a New Storage Device for Cold Preservation

The Journal of Heart and Lung Transplantation, Vol. 40, Issue 4

J. Gökler, P. Angleitner, R. Moayedifar, H. Johann, A. Aliabadi-Zuckermann, G. Laufer, A. Zuckermann

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Cardiac Transport System

Heart

GUARDIAN Publications

First Report of the GUARDIAN Registry: An International Consortium Examining the Effect of Controlled Hypothermic Preservation in Heart Transplantation

The Journal of Heart and Lung Transplantation, Vol. 40, Issue 4

D. D’Alessandro, J.Philpott, T. Boeve, S. Pham, A. Zuckermann

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Heart

Primary Graft Dysfunction

Primary Graft Dysfunction after Heart Transplantation – Unravelling the Enigma

Current Problems in Cardiology, 2022 August, Volume 47, Issue 8, pp:100942

A. Al-Adhami, S. A. Singh, S. D. De, R. Singh, G. Panjrath, A. Shah, J. R. Dalzell, J.Schroder, N. Al-Attar

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Cardiac Transport System

Heart

Controlled temperatures in cold preservation provides safe heart transplantation results

Transplantation Journal of Thoracic Disease

M. Bitargil, O. Haddad, S. Pham, R. Goswami, P. Patel, S. Jacob, M. El-Sayed Ahmed, J.C. Leoni Moreno, D. Yip, K. Landolfo, B. Sareyyupoglu

Clinical Publications