Organ Transport Solutions
Paragonix Technologies' primary goal is to improve transplant patient outcomes and optimize donor organ utilization.
Organ Transport Solutions
Paragonix Technologies primary goal is to improve transplant patient outcomes and optimize donor organ utilization.
Current Methods for Transporting Donor Organs are Outdated and Unpredictable
Current Methods for Transporting Donor Organs are Outdated and Unpredictable
Problem
Current Cooler Method Provides Unpredictable Donor Organ Cooling
Rapid Temperature Decrease to Below 2°C
- Multi-center clinical study found average organ temperature during ice cooler transportation (n=186) was below 2°C and below 0°C after 6 hours1
- Preclinical porcine study found apex temperature below 2°C in 30 minutes and ventricle below 2°C in 150 minutes2
- Preclinical cardiac canine study found right ventricle, left ventricle, and septum below 1°C in 75 minutes and below 0°C in 4 hours3
Known Risks Below 2°C
< 2°C: Cold injury 4-7
Known Cardiac Risks Below 2°C
< 1°C: Irreversible suppression of diastolic function8
< 0°C: Proteins denature 4-7
Paragonix Provides an Advanced Solution
ICE STORAGE
- Historic method of preserving and transporting organs
- Uses plastic bags, ice, and consumer ice coolers
- Non-FDA regulated devices
- Un-controlled, un-monitored cooling
- Risks cellular injury to transported organ
- FDA cleared and CE marked device for preservation and transportation of donor organs
- Repeatable process to protect donor organ in transit
- Real-time monitoring, tracking, and communication
- Over 1400 organs preserved since 2019
How it Works
Paragonix SherpaPak®
CARDIAC TRANSPORT SYSTEM
Paragonix Guard Series
DONOR LUNG & LIVER PRESERVATION SYSTEMS
Paragonix SherpaPak® CTS
Cardiac Transport System Features
Precision Cooling System
Paragonix SherpaCool™ ribbons’ proprietary phase change technology prevent exposure to excessive temperature reduction
Mechanically Isolated Protection
Rigid, pressure controlled, leakproof dual-canister system protects heart from physical and thermal trauma
Stable Preservation Environment
Lightweight shipper system is validated for a consistent thermal environment for over 40 hours
Connected Data Driven Monitoring
Real-time monitoring and data reporting via Bluetooth® connection and the Paragonix App
Caution: Federal (US) law restricts this device to sale by or in the order of a licensed health care practitioner. Please refer to Instructions for Use for full prescribing information. Cleared indication is for 4-hour use. Patents issued and pending. See Indications For Use for more information.
Paragonix LUNGguard™
Donor Lung Preservation System Features
Stable Temperature Between 4-8°C
The LUNGguard system is validated to maintain temperatures of donor lungs between 4-8°C for over 44 hours.
A Safety Vault for Donor Lungs
Lungs are placed inside a secure vault to maintain the shape of the lungs and prevent physical trauma during transport
Organ Temperature Monitoring
The lungs are placed on a tray with an embedded temperature probe that continuously measures the temperature of the preservation solution
Connected Data Driven Monitoring
Real-time monitoring and data reporting via Bluetooth® connection and the Paragonix App
Caution: Federal (US) law restricts this device to sale by or in the order of a licensed health care practitioner. Please refer to Instructions for Use for full prescribing information. Cleared indication is for 8-hour use. Patents issued and pending. See Indications For Use for more information.
Paragonix LIVERguard™
Donor Liver Preservation System Features
Stable Preservation
Lightweight shipper system is validated for a consistent thermal environment for over 40 hours
Precision Cooling System
Prevent exposure to excessive temperature reduction utilizing proprietary SherpaCool™ phase change technology
Mechanically Isolated Protection
Rigid tray and rack structure encapsulates triple bag isolation system, providing added protection from physical and thermal trauma
Connected Data Driven Monitoring
Real-time monitoring and data reporting with Paragonix App via Bluetooth® enables connected communication among donor and recipient transplant teams
Caution: Federal (US) law restricts this device to sale by or in the order of a licensed health care practitioner. Please refer to Instructions for Use for full prescribing information. Cleared indication is for 15-hour use. Patents issued and pending. See Indications For Use for more information.
Advancing Donor Organ Preservation
HEART
LUNG
LIVER
KIDNEY
Kidney KTS
Kidney Transport System
Coming Soon
PANCREAS
Pancreas PTS
Pancreas Transport System
Coming Soon
2. Validation data on file with Paragonix Technologies
3. Hendry et al., J Thorac and Cardiovasc Surg 1989
4. Michel et al. Ann Transplant 2014
5. Michel et al. Ann Transplant 2015
6. Ingemansson et al., Ann Thorac Surg 1996
7. Mankad et al., J Thorac and Cardiovasc Surg 1992
8. Keon et al., Ann Thorac Surg 1988
