Paragonix LUNGguard®

Donor Lung Preservation System

One of the leading FDA-cleared and CE-marked preservation devices for lung transportation, the Paragonix LUNGguard® offers a sterile, controlled environment that protects donor lungs from both physical and thermal damage.

Over 500

Donor lungs preserved

Over 80

Transplant centers

Over 35

Clinical publications

Advancing Lung Preservation

The endothelium of the lung is an extremely vulnerable tissue. Outside of the body, cells once safeguarded by protective homeostatic conditions are suddenly exposed to a highly variable environment, which can cause harm to such an important layer of tissue. Traditionally, donor lungs destined for transplantation were placed into commercial-grade coolers filled with ice to transport it to the recipient. This method presents a multitude of uncontrolled variables that can also impact the post-transplant function of the lung. Clinical evidence has shown that the use of ice can expose the donor lung to freezing temperatures, leading to irreversible cellular damage.¹

The Paragonix LUNGguard is an Advanced Organ Preservation device specifically designed to standardize the variables of donor lung preservation, providing physicians with stable cooling technology driven by real-time data monitoring.

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Caution: Federal (US) law restricts this device to sale by or in the order of a licensed health care practitioner. Please refer to Instructions for Use for full prescribing information. Cleared indication is for 8-hour use. Patents issued and pending. See Indications For Use for more information.

Technological Advantage of Advanced Organ Preservation

Traditional Ice Storage

Uses commercial-grade coolers unregulated by the FDA
Exposes the the donor lung(s) to an unmonitored environment of 0°C ice
Lung tissue is exposed to uneven cooling, potentially risking freezing injury
Unpredictable temperature reductions within the ice cooler are not monitored during transport

Paragonix LUNGguard

An FDA-cleared and CE-marked preservation device intended to protect the donor lung(s) in transit
Validated to maintain a consistent thermal environment
Utilizes SherpaCool® phase-change technology to prevent exposure to excessive temperature reduction
Records temperature, location, and case status in real-time

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Rigid Outer Shell

Protective polystyrene material ensures internal environment will maintain temperature over 40 hours

SherpaCool Technology

Proprietary phase-change cooling formula that maintains optimal temperature conditions without the use of 0°C ice

Triple Bag System

Industry-standard, best-in-class bagging system

Temperature Probe

Embedded probe continuously monitors and records the internal and ambient temperatures

Monitor and Data Transmission

Simple Bluetooth® pairing allows the system to transmit full data reports to as many users as necessary

Advancing the Science of Preservation

To measure the clinical impact of advanced lung preservation, Paragonix leads the novel GUARDIAN-Lung Clinical Registry. Our panel of clinical investigators analyze the post-transplant outcomes of the LUNGguard in comparison to traditional ice storage.

The GUARDIAN-Lung study is a post-market, observational registry of lung transplant recipient patients whose donor lung was preserved and transported using the Paragonix LUNGguard® Donor Lung Preservation System. The data is being collected retrospectively from medical records of patients already transplanted before the initiation of the registry and any new patients who meet the eligibility criteria.

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Follow your transplant’s journey from beginning to end

The Paragonix App and Web Portal allows transplant teams to coordinate case logistics in a centralized, secure platform designed specifically for use in a real-world setting. And, if greater logistical support is needed, you can rely on our network of experienced personnel to expand your surgical coverage.

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Important Safety Information

Indications for Use

The Paragonix LUNGguard® (LUNGguard®) is intended to be used for the static hypothermic preservation of lungs during transportation and eventual transplantation into a recipient using cold storage solutions indicated for use with the lungs.The intended organ storage time for LUNGguard® is up to 8 hours.Donor lungs exceeding clinically accepted static hypothermic preservation times should be evaluated by the transplant surgeon to determine transplantability in accordance with accepted clinical guidelines and in the best medical interest of the intended recipient.

Note: Partial lungs can be transported via LUNGguard® by packaging lungs per institutional protocol and UNOS guidelines.

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